Traveling with Weight Loss Medication like Wegovy® & Zepbound®?

By Dana Babeu, Registered Dietitian with 14 years of specialized experience in weight management and bariatric nutrition at New Jersey Bariatric Center® 

Medically Reviewed by Ajay Goyal, MD, FACS

Planning a vacation while taking semaglutide (Ozempic®, Wegovy®), tirzepatide (Mounjaro®, Zepbound®), or other GLP-1 medications? You are not alone. With more than 15 million Americans now using these medications, knowing how to travel safely with your prescription is essential.

Recently, I helped a patient who was worried about traveling to Africa with her Zepbound® prescription. Like many of our patients, she was concerned about medication storage during her 15 hour flight and whether she'd face travel issues. Her successful trip—with proper planning—inspired this comprehensive guide to help others navigate similar challenges. As a registered dietitian for the past 14 years, I’m often asked what’s the best way to travel with weight loss medication. From packing and storage requirements, to airline travel and meal planning, the New Jersey Bariatric Center® team of weight loss specialists compiled this guide with you in mind. Before we continue, it’s important to check with your doctor before making any changes to your dosing schedule.

Can You Travel with Weight Loss Medications? 

Short Answer: Yes, you can travel with weight loss medications. According to pharmaceutical manufacturers, medications like Ozempic®, Wegovy®, Mounjaro®, and Zepbound® can be safely transported when stored correctly. 

The key to successful travel lies in understanding temperature requirements and having a solid backup plan. Dr. James Buwen, a New Jersey Bariatric Center®’s weight loss specialist, emphasizes: "Most travel complications arise from inadequate temperature control, not the travel itself." In general, it is best to avoid prolonged time at or above room temperature and when in doubt, our weight loss experts advise disposing of the medication.

Temperature Control: The #1 Priority for GLP-1 Storage

Temperature control is key, so be sure to keep doses in an insulated bag with ice packs and refrigerate immediately upon arriving at your destination. The exact amount of time medications can remain at room temperature varies by brand and patients should refer to the manufacturer’s instructions. 

GLP-1 medications are temperature-sensitive and require consistent refrigeration between 36°F and 46°F (2°C to 8°C) before opening and taking your first dose. 

Room Temperature Limits by Medication After Opening and The First Dose is Taken:

• Semaglutide (Wegovy): Up to 28 days at room temperature (max 86°F)
• Semaglutide (Ozempic): Up to 56 days at room temperature (max 86°F)
• Tirzepatide (Mounjaro/Zepbound): Up to 21 days at room temperature (max 86°F)
• Liraglutide (Saxenda): Up to 30 days at room temperature (max 86°F)

It’s important to note that if your medication has been exposed to extreme temperatures, frozen or you're unsure about storage conditions, consult your doctor before your next dose.

How to Pack GLP-1 Medications for Travel

When packing your glp-1 medication for travel, this is a list of essential packing supplies and methods to consider: 

Essential Packing Supplies:

1. Insulated medication bag (pharmacy-grade cooling bags work best)
2. Gel ice packs (frozen solid before departure)
3. Digital thermometer to monitor temperature
4. Backup ice packs for longer trips
5. Prescription labels and doctor's letter

Avoid letting the medication touch the ice packs directly, as this can cause it to freeze. Freezing can damage the protein-based drug, rendering it less effective or completely ineffective. Use a protective layer, such as a towel, to maintain a cool temperature. Just as freezing temperatures can harm GLP-1 medications, excessive heat poses an equally serious threat to their effectiveness.

Heat can reduce a GLP-1 medication’s potency, making it less effective. It is recommended to discard the medication and use a new pen if it has been exposed to temperatures exceeding its stated room temperature. Common examples of extreme heat exposure include leaving the medication in direct sunlight for an extended period or inside a hot car or trunk.

Storing Weight Loss Medications While Traveling

Weight loss medications like semaglutide  (Ozempic®, Wegovy®), and tirzepatide (Mounjaro®, Zepbound®) should be stored in an insulated container with cold packs until they can be refrigerated upon reaching your destination. To pack, pre-freeze gel ice packs for at least 4 hours, wrap your medications in bubble wrap or towel, and place a thermometer inside the cooling bag to monitor temperature. Some travelers question whether they should keep their weight loss medication in a carry on bag or check it in when flying. 

For up-to-date information, check the TSA regulation for storage protocols. If there is an option to put your medication in a checked-in luggage, note that due to exposure to extreme temperature fluctuations in the cargo hold, this can degrade the medication. It may be better to store it in your carry-on bag.

Flying with Semaglutide & Tirzepatide

The Transportation Security Administration (TSA) has specific protocols for flying with injectable medications like semaglutide and tirzepatide. In addition to properly storing your GLP-1 medications during travel, be sure to check with your airline ahead of time regarding their specific policies. 

Airlines may allow traveling with weight loss medications in carry-on luggage, stored cold, with a copy of your prescription and declaring any syringes/pens to TSA officers. While not required, it is recommended to label your medications to facilitate the security process. Additionally, it is advisable to travel with contact phone numbers for your prescribing physician and pharmacy. 

Along with contact phone numbers, be sure to carry your prescription, including your name, pharmacy name, and physician/MD names. 

Plan Your Meals and Exercise 

In addition to making a plan for medication, be sure to talk with your dietitian about how you plan to eat while away. Traveling with supplements like protein powder, bars and good quality meat sticks can be a great way to stay on track with your goals. 

Be intentional about when and how you will indulge with eating out or enjoying a cocktail. Walking, sightseeing, hotel gyms, excursions and dancing while traveling can provide ample opportunities for physical activity.

What If I Miss Doses While Traveling

The good news is that GLP-1 medications can be safely skipped for up to one week without major concerns.  However, if you’ll be away from your medication for more than 7 days, it is crucial to consult with your provider before resuming treatment. Dr. Buwen emphasizes the importance of this consultation, as your provider might need to lower your dosage to avoid significant side effects like nausea and vomiting which can lead to dehydration. These side effects can occur because resuming the medication at the same dosage level after 7 days is akin to a first-time encounter for your body.

Medication Storage Emergencies

If your medication gets too warm or too cold, don't panic—assess the situation objectively by checking the exact temperature and duration of exposure. Contact your pharmacy or doctor immediately for guidance, and avoid using medication if you suspect it's been compromised by heat or cold exposure.

If you forget your medication, start by contacting your prescribing doctor. You can also search for local pharmacies that may have your medication in stock or consider telemedicine consultations for prescription transfers. Keep your pharmacy and insurance information easily accessible to expedite this process.

Travel Insurance With Weight Loss Medication

While it is not required to purchase travel insurance, it is highly recommended. Some travel insurance policies may cover prescription medications. Coverage can vary between policies and plans. When selecting coverage, look for policies that include prescription replacement due to loss or spoilage, emergency medical consultations, and coverage for medication cooling requirements during travel delays. This additional protection can save both money and stress if unexpected situations arise during your trip.

Can I Receive A Temporary Prescription From A Local Doctor  

In many cases, it may be possible to get a temporary prescription for your GLP-1 medication from a local doctor while traveling internationally, however there are several factors to consider which are checking the specific regulations for controlled substances, and contact the embassy or consulate of the destination country to confirm what documentation you’ll need, like a doctor’s note or import permit. 

As a precaution, research telemed options in the location you are traveling to in case your medications get compromised. Having a backup plan for medication emergencies ensures you can handle unexpected situations while maintaining your weight loss progress.

For any questions or concerns, call us at 908-481-1270. 

Frequently Asked Questions About Traveling with GLP-1 Medications

1. Can I travel internationally with GLP-1 medications like semaglutide & tirzepatide?

Most destinations allow you to travel with GLP-1s, we recommend you always research your destination's medication policies beforehand. Some countries may require additional documentation or have quantity restrictions.

2. How do I handle time zone changes with injection schedules?

Gradually adjust injection times by 1-2 hours per day when crossing multiple time zones. Consult your doctor for trips involving significant time differences.

3. What if my hotel doesn't have a refrigerator?

Most hotels can provide mini-fridges upon request. If unavailable, ask front desk staff to store your medication in their kitchen refrigerator with proper labeling.

**Important Medical Disclaimer:** This guide provides general information for educational purposes only and should not replace individualized medical advice. GLP-1 medication requirements may vary based on your specific prescription, dosage, and medical history. Always consult your healthcare provider before traveling, especially for international trips or extended travel periods.

Key Takeaways:

• Temperature control is critical for medication effectiveness
• Carry medications in carry-on luggage with TSA-approved cooling
• Plan for potential delays and emergencies
• Maintain healthy eating and exercise habits while traveling
• For long-term travel, stay in communication with your weight loss team
• Check your destination’s policy on GLP-1 medications before travelling

References:

(2025). GLP-1 RAs Storage and Stability. Novo Nordisk Medical,

https://www.novonordiskmedical.com//product-information/storage-and-stability/glp-1-ras.html

Koprowski, B. (2025). Does Mounjaro need to be refrigerated? MedicalNewsToday,

https://www.medicalnewstoday.com/articles/drugs-mounjaro-refrigerated

Sissons, B. (2025). Zepbound refrigeration and storage needs. MedicalNewsToday,

https://www.medicalnewstoday.com/articles/drugs-does-zepbound-need-to-be-refrigerated

(2025). Storing GLP-1: Best Practices For Safety and Potency. TrimBody M.D.,https://www.trimbodymd.com/faqs/storing-glp-1/#:~:text=Before%20first%20use:%20Store%20pens,shield%20the%20pen%20from%20light