Wegovy® vs. Ozempic®: What is the Difference?      

Key Takeaways

• Different FDA Approvals: Wegovy® is FDA-approved specifically for chronic weight management in adults with obesity (BMI ≥30) or weight-related conditions (BMI ≥27), while Ozempic® is FDA-approved only for type 2 diabetes management.
• Same Active Ingredient, Different Dosages: Both medications contain semaglutide, but Wegovy® has a higher maximum dose (2.4 mg weekly) vs. Ozempic® (2.0 mg weekly).
• Weight Loss Results Differ: Clinical trials show Wegovy® patients achieve approximately 15-18% weight loss over 68 weeks, while Ozempic® results in 8-14% weight loss when used at diabetes treatment doses.
• Insurance Coverage Varies: Ozempic® is typically covered by insurance for type 2 diabetes, while Wegovy® coverage depends on individual insurance plans' weight loss medication policies and usually requires prior authorization.
• Medical Supervision Required: Both medications require a prescription and ongoing medical monitoring to ensure safety and effectiveness.

Wegovy® vs. Ozempic®? As a weight loss doctor at the New Jersey Bariatric Center® a common question from patients is what’s the difference between these two medications. While both medications are manufactured by Novo Nordisk®, have semaglutide as the key active ingredient and can contribute to weight reduction, Ozempic® is only FDA-approved for the management of type 2 diabetes, not weight loss. Wegovy® is FDA-approved for chronic weight management in adults with obesity or weight-related conditions. 

Wegovy® vs. Ozempic® Dosage Comparison

Both medications' active ingredient is semaglutide, a GLP-1 inhibitor. Wegovy® is administered at a maximum dose of 2.4 mg weekly, whereas Ozempic®'s maximum dose is 2.0 mg. The higher dosage in Wegovy® may contribute to greater weight loss in eligible patients.

Wegovy® vs. Ozempic® Results

Clinical trials indicate that patients using Wegovy® achieve an average weight loss of approximately 15-18% over 68 weeks with healthy eating and exercise. In comparison, weight reduction with Ozempic®, when prescribed at type 2 diabetes treatment doses, ranges from 8-14% with healthy eating and exercise. Additionally, Ozempic® is effective in improving blood sugar levels and lowering cardiovascular risk in individuals with type 2 diabetes. At New Jersey Bariatric Center® we understand that weight loss medication coupled with proper nutrition and exercise are essential. Our doctor-led, medical weight loss program includes guided healthy eating habits and monthly yoga and exercise classes to support our patients health goals.  

Is Wegovy® more Expensive than Ozempic®? Cost and Insurance Coverage?

Without health insurance coverage, wegovy® may be more expensive than ozempic®, depending on the pharmacy and location. Consult with your pharmacy for the most accurate rates. The approximate monthly cost for both medications range from $650 to $1,500 out of pocket for a 28 day supply. Insurance coverage varies significantly between these medications. Ozempic® is typically covered by insurance when appropriate documentation for Type 2 diabetes is provided. Whether insurance covers Wegovy® is dependent on individual insurance plans weight loss medication coverage and typically requires prior authorization. Patients should verify their insurance benefits before discussing treatment options with their healthcare provider.

Ozempic® vs Wegovy® Side Effects

Ozempic® and Wegovy® medications share similar side effects because they both contain semaglutide. Common adverse effects for both include gastrointestinal symptoms such as nausea, vomiting, and diarrhea, when starting treatment. In rare cases, some patients may develop complications such as pancreatitis and gallbladder disease. These medications are not recommended in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. Routine monitoring of kidney function, thyroid health, and overall treatment response is recommended while taking Ozempic® or Wegovy®.

What are the Requirements to Qualify for Wegovy® vs. Ozempic®?

• Wegovy®: Suitable for patients with a body mass index (BMI) of ≥30, or ≥27 with weight-related comorbidities. Patients should not have a history of thyroid malignancy or pancreatitis. Incorporating lifestyle changes such as healthy eating and exercise is important. 
• Ozempic®: Recommended for individuals diagnosed with type 2 diabetes and needs to control their blood sugar levels. While weight loss may occur, the primary purpose is diabetes management. Candidates should have stable renal function and understand that weight management is a secondary benefit of this medication.

Medical Supervision and Monitoring

Ongoing medical supervision is critical to ensure the safety and efficacy of any weight loss medication treatment. At New Jersey Bariatric Center® your weight loss team will conduct health assessments while you're on weight loss medications, including kidney function tests and dose adjustments. This protocol helps to minimize side effects, and monitor how well you tolerate the medication. Results may vary based on patient follow-ups, lifestyle changes and adherence to prescribed protocols.

Frequently Asked Questions

How do Wegovy® and Ozempic® differ?

Both of these Novo Nordisk® medications contain semaglutide. Wegovy® is specifically indicated for weight management, achieving an average weight loss of 15-18%. Ozempic® is primarily indicated for type 2 diabetes treatment, with weight loss of 8-14% as a secondary effect. Wegovy® is administered at a higher maximum dose (2.4 mg) compared to Ozempic® (2.0 mg).

What are the costs and insurance coverage options? 

Without insurance, the cost of both medications range between $650 and $1,500 for a 28 day supply. Ozempic® is typically covered by insurance for type 2 diabetes treatment. Coverage for Wegovy® varies and generally requires prior authorization.

Can Ozempic®be prescribed for weight loss in non-diabetic patients?

Ozempic® is FDA-approved for type 2 diabetes management. Off-label prescribing for weight loss is at the discretion of the prescribing doctor. Keep in mind that insurance coverage varies and may not be available for this medication if prescribed without documentation of type 2 diabetes.

What are the common side effects? 

Most patients experience mild gastrointestinal discomfort, such as nausea, which can be managed with gradual dose adjustment. Serious but rare adverse effects include pancreatitis and gallbladder disease.

Do these medications require a prescription? 

Yes, both Wegovy® and Ozempic® require a prescription and ongoing medical supervision.

Can patients switch between these medications? 

Medication changes should only occur under medical supervision by a board certified doctor due to differences in dosing protocols and regulatory approvals. Your doctor can determine the most appropriate based on your medical history, type 2 diabetes status and weight loss goals.

Are Wegovy® and Ozempic® available in New Jersey?

Yes, both medications are available in New Jersey. For more information on weight management and type 2 diabetes treatment options, schedule a consultation with a New Jersey Bariatric Center® doctor to discuss your individualized needs.

Patients should consult their healthcare provider to determine the most suitable treatment option.